Science 285: 1923-1926 (1999), 11)           Korswagen, R., Herman, M. and Clevers, H. Separate beta-catenins mediate Wnt signaling and cadherin adhesion in C. elegans. A springboard for senior group leaders. Here, several important advances in developmental biology were made, including the pioneering work of Pieter Nieuwkoop, after whom the area of an embryo called the “Nieuwkoop center” is named. Cell 111: 241-250 (2002), 14)           Batlle, E., Henderson, J.T., Beghtel, H., van den Born, M., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., van de Wetering, M., Pawson, T., Clevers, H. Beta- catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. At the beginning of the 1880s Hubrecht corresponded with Charles Darwin, who paved the way for the theory of evolution in his book “On the origin of species”. Stem cells numbers remain fixed because stem cells compete ‘neutrally’  for niche space. Tumour suppressor RNF43 is a stem cell E3 ligase that induces endocytosis of Wnt receptors. Patient-derived organoids hold promise to predict drug response in a personalized fashion and open up new avenues for regenerative medicine and, in combination with genome editing technology, for gene therapy. Cell 111: 251-263 (2002), 15)           Hurlstone, A.F., Haramis, A.P., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R.H., Clevers, H. The Wnt/beta-catenin pathway regulates cardiac valve formation. floxed), Reporter) Gt(ROSA)26Sor: gene … Hans Clevers is both group leader at the Hubrecht Institute and scientific director of the PMC, ensuring a steady relationship. The impact score places the Hubrecht also as one of the premier biology research institutes world-wide. and Clevers, H.C. An HMG box containing T-cell factor required for thymocyte differentiation. h.clevers@hubrecht.eu. Lgr5 resides in Wnt receptor complexes and mediates signaling of the R-spondin Wnt agonists (33), explaining the unique dependence of Lgr5 stem cells of various epithelia on R-spondins in vivo and in vitro. Utrecht Science Park is only 15 minutes away from downtown Utrecht: a lively, charming university town. 2017 – present  Shaw Prize, Hong Kong H Clevers. Johannes Carolus (Hans) Clevers is Principal Investigator at the Hubrecht Institute for Developmental Biology and Stem Cell Research (KNAW) and the Princess Máxima Center for Pediatric Oncology, Professor of Molecular Genetics at the UMC Utrecht and Utrecht University, and Oncode Investigator. The Wnt target gene encoding the transcription factor Achaete scute-like 2 controls the fate of the intestinal stem cell (26). Lgr5 crypt stem cells behave in unanticipated ways: Against common belief, they divide constantly. Towards a better treatment . Nature Genetics 40: 1291-1299 (2008), 25)           Barker, N., Ridgway, R.A., van Es, J.H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A.R., Sansom, O.J., Clevers, H. Crypt Stem Cells as the Cells-of-Origin of Intestinal Cancer. Verbeek, J.S., Ison, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M., Wilson, A., MacDonald, H.R. The Hubrecht Institute has a tight collaboration with the UU on multiple levels: there is a lot of scientific collaboration, several PI’s are appointed as professor at the UU, all Hubrecht PhD students participate in the Graduate School of Life Sciences and various Master students perform their internships at one of the Hubrecht groups. Hubrecht Organoid Technology. These lab-grown mini glands produce and secrete active toxins found in snake venom. Hans Clevers (Hubrecht Institute) states: "These organoids contain the cells of the human intestinal lining, making them a compelling model to investigate infection by SARS-CoV-2." Research at the Hubrecht Institute is pioneering in developmental and stem cell biology. 9 Hubrecht Organoid Technology, Utrecht, The Netherlands. 2001    Spinoza Award of the Netherlands Research Council (NWO) The KNAW is the forum, conscience, and voice of the arts and sciences in the Netherlands. 2000               Member of the Royal Netherlands Academy of Sciences (KNAW) Nature 374: 70-74 (1995), 3)              Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H.Sox-4 gene is required for cardiac outflow tract formation and pro-B lymphocyte expansion. Two other Wnt target genes, RNF43 and ZNRF3, encode stem cell-specific E3 ligases that downregulate Wnt receptors. The Hubrecht aims to be a springboard for talent and offers its employees the opportunity for personal and professional development, through a wide variety of workshops and courses, including those organized by our mother organization the Royal Netherlands Academy of Arts and Sciences (KNAW). The Hubrecht Institute and PMC collaborate, especially using tumor organoids, single cell sequencing and intravital imaging of tumors. Review The Hubrecht Institute provides an infrastructure that embeds the group in an efficient facility support so that group leaders can focus on the research. Dr. Clevers received his M.D. Hubrecht Institute Centennial – From embryos to stem cells The Hubrecht Institute and PMC collaborate, especially using tumor organoids, single cell sequencing and intravital imaging of tumors. The scientific advisory board of the Hubrecht Institute meets once a year and is involved in the tenure track evaluations of the junior PI’s. 1991 – 2002      Professor and Chairman, Dept. Science 327: 1385-1389 (2010), 30)           Sato, T., van Es, J.H., Snippert, H.J., Stange, D.E., Vries, R.G., van den Born, M., Barker, N., Shroyer, N.F., van de Wetering, M., Clevers, H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Read More + Genetic overview. As a patient-centered organization, its 11,000 employees are dedicated to prevent disease, improve healthcare, develop new treatment methods and refine existing ones, with quality and patient safety as cornerstones. For example, during the last year more than half of the top publications from the Hubrecht Institute involved more than two Hubrecht groups, demonstrating the collaborative spirit. Cell Stem Cell 13: 653-658 (2013), 44)           Ritsma, L., Ellenbroek, S.I., Zomer, A., Snippert, H.J., de Sauvage, F.J., Simons, B.D., Clevers, H., van Rheenen, J. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Princess Máxima Center for pediatric oncology (PMC) Oncode Institute is a virtual, independent research institute dedicated to outsmarting cancer and impacting lives. 2016 – 2020      Member of the Scientific Advisory Board of Kallyope, New York Maurice, M.M. 11 Oncode Institute, Hubrecht Institute-KNAW and UMC Utrecht, Utrecht, The Netherlands h.clevers@hubrecht.eu. Review 2016 – present  Member of the Scientific Advisory Board of Surrozen, San Francisco In 1991, we reported the cloning of a T cell specific transcription factor that we termed TCF1 (1). Utrecht University is an international research university of the highest quality and the alma mater of many leading names, academics and scientists who have made an important contribution to the quality of society. 2013 – 2015      Canada Gairdner Award, Toronto So says Robert Vries, who has been working since 2013 to make HUB (Hubrecht Organoid Technology) the … 2006 – 2008      President of the International Society of Differentiation (ISD) Johannes Carolus (Hans) Clevers (born 27 March 1957) is Principal Investigator at the Hubrecht Institute for Developmental Biology and Stem Cell Research (KNAW) and the Princess Máxima Center for Pediatric Oncology, Professor at Utrecht University and Oncode Investigator. Nature 530: 340-343 (2016), 51)           Clevers, H. Modeling development and disease with organoids Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or … 2016    The Ilse & Helmut Wachter award, Hamburg, Germany During his life Hubrecht assembled a vast amount of embryonic material from a number of species, particularly from the former Dutch colonies of the East Indies. (2)Hubrecht Institute for Developmental Biology and Stem Cell Research, Oncode Institute, University Medical Centre Utrecht, Upsalalaan 8, 3584CT Utrecht, The Netherlands; Princess Máxima Center for Pediatric Oncology, 3584CT Utrecht, The Netherlands. In addition to a highly interactive and international scientific environment, excellent research facilities are available on-site. Science  358: 234-238 (2017). and Clevers, H. de Lau, W., Barker, N., … and Clevers, H. Li, V.S., Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T. and Clevers, H. Snippert, .J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N.,Klein, A.M., van Rheenen, J. Benjamin D. Simons, B.D. The board of directors, consisting of Prof. Alexander van Oudenaarden (director) and Prof. Jeroen den Hertog (managing director) maintains a flat organizational structure with tenure track positions for junior group leaders. About. h.clevers@hubrecht.eu. 2018    Academia Europaea Erasmus Medal, Barcelona, Spain The Dana-Farber cancer Institute of Metabolic Science, Seattle, WA, USA cell: mechanism and applications origin. 1916, after Hubrecht ’ s death, the Netherlands h.clevers @ hubrecht.eu cell sequencing and intravital imaging tumors. Hubrecht is affiliated with the biology of Wnt signaling in development and homeostasis organs! 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